Synthesis and biological evaluation of 1,2-disubstituted carbonucleosides of 6-substituted purine and 8-azapurine

Authors
Santana, L Teijeira, M Uriarte, E Teran, C Andrei, G Snoeck, R Balzarini, J De Clercq, E
Citation
L. Santana et al., Synthesis and biological evaluation of 1,2-disubstituted carbonucleosides of 6-substituted purine and 8-azapurine, NUCLEOS NUC, 18(4-5), 1999, pp. 733-734
Citations number
1
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
4-5
Year of publication
1999
Pages
733 - 734
Database
ISI
SICI code
0732-8311(1999)18:4-5<733:SABEO1>2.0.ZU;2-P
Abstract
A series of new one two subtituted carbonucleoside analogues (OTC), with th e purine and 8-azapurine base linked through a methylene group at the cyclo pentane ring, were synthesized and evaluated for their activity against a n umber of viruses and tumor cells in vitro.