Synthesis and receptor affinity of polysubstituted adenosines

Authors
Vittori, S Camaioni, E Costanzi, S Volpini, R Klotz, KN Cristalli, G
Citation
S. Vittori et al., Synthesis and receptor affinity of polysubstituted adenosines, NUCLEOS NUC, 18(4-5), 1999, pp. 739-740
Citations number
5
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
4-5
Year of publication
1999
Pages
739 - 740
Database
ISI
SICI code
0732-8311(1999)18:4-5<739:SARAOP>2.0.ZU;2-H
Abstract
In a search for potent and selective adenosine agonists it has been found t hat 2-hexynyladenosine-5'-N-ethyluronamide (HENECA) displays high affinity at rat A(2A) receptor combined with a good A(2A) vs A(1) selectivity. The f inding that HENECA shows good affinity also for A(3) receptors prompted us to investigate the effect of various substituents in different positions of this molecule.