Design and SAR study of a novel class of nucleotide analogues as potent anti-HCMV agents.

Authors
Nguyen-Ba, N Chan, L Quimpere, M Turcotte, N Lee, N Mitchell, H Bedard, J
Citation
N. Nguyen-ba et al., Design and SAR study of a novel class of nucleotide analogues as potent anti-HCMV agents., NUCLEOS NUC, 18(4-5), 1999, pp. 821-827
Citations number
9
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
4-5
Year of publication
1999
Pages
821 - 827
Database
ISI
SICI code
0732-8311(1999)18:4-5<821:DASSOA>2.0.ZU;2-W
Abstract
We have developed a novel class of 2-phosphonate 1,3-dioxolane nucleotide a nalogues, from which the guanine derivative displayed weak anti-HCMV activi ty. Further SAR studies led to the identification of both cis and trans gua nine derivatives of tetrahydrofuran analogues as potent anti-HCMV agents, b oth in vitro and in vivo, compared to ganciclovir and HPMPC.