Synthesis and biological evaluation of polyaminated 2 ',3 '-dideoxy-3 '-thiacytidine prodrugs

Authors
Camplo, M Mourier, N Chermann, JC Kraus, JL
Citation
M. Camplo et al., Synthesis and biological evaluation of polyaminated 2 ',3 '-dideoxy-3 '-thiacytidine prodrugs, NUCLEOS NUC, 18(4-5), 1999, pp. 879-880
Citations number
6
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
4-5
Year of publication
1999
Pages
879 - 880
Database
ISI
SICI code
0732-8311(1999)18:4-5<879:SABEOP>2.0.ZU;2-8
Abstract
The syntheses and biological evaluation of polyaminated 2',3'-dideoxy-3'-th iacytidine have been performed. A new lead was found to increase the in vit ro antiviral potency (syncitia formation on MT-4 cell line) of two order ma gnitude greater than the parent nucleoside drug. Moreover, the in vitro act ivity on HIV macrophages was found to be more than 3 log greater than the a ctivity of the parent drug 1.