New polyazamacrocycle-nucleoside conjugates : Synthesis, anti-HIV evaluation and interaction with CXCR-4 coreceptor

Authors
Dessolin, J Galea, P Vlieghe, P Chermann, JC Kraus, JL
Citation
J. Dessolin et al., New polyazamacrocycle-nucleoside conjugates : Synthesis, anti-HIV evaluation and interaction with CXCR-4 coreceptor, NUCLEOS NUC, 18(4-5), 1999, pp. 881-882
Citations number
3
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
4-5
Year of publication
1999
Pages
881 - 882
Database
ISI
SICI code
0732-8311(1999)18:4-5<881:NPC:SA>2.0.ZU;2-L
Abstract
We report the synthesis of new conjugates that incorporate in their structu re bis-tetraazamacrocycle coupled with AZT via enzymolabile bond. Two series of bis-polyazamacrocycles-AZT conjugates were designed, synthesi zed and evaluated for their antiviral effect in vitro as well as their capa bility to bind to CXCR-4 coreceptor.