L-purine nucleosides as selective antimalarials

Authors
Gero, AM Perrone, G Brown, DM Hall, ST Chu, CK
Citation
Am. Gero et al., L-purine nucleosides as selective antimalarials, NUCLEOS NUC, 18(4-5), 1999, pp. 885-889
Citations number
9
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
4-5
Year of publication
1999
Pages
885 - 889
Database
ISI
SICI code
0732-8311(1999)18:4-5<885:LNASA>2.0.ZU;2-Z
Abstract
L-nucleosides selectively enter malaria infected erythrocytes and have the unique ability to be metabolised by the malarial adenosine deaminase. This has allowed us to design novel L-nucleosides as potential anti-malarials.