Citation
Zx. Gu et al., Anti-HIV-1 activities of 1,3-dioxolane guanine and 2,6-diaminopurine dioxolane, NUCLEOS NUC, 18(4-5), 1999, pp. 891-892
Citations number
2
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311
→ ACNP
Volume
18
Issue
4-5
Year of publication
1999
Pages
891 - 892
Database
ISI
SICI code
0732-8311(1999)18:4-5<891:AAO1GA>2.0.ZU;2-X
Abstract
DXG and its prodrug DAPD have been demonstrated to be effective inhibitors
of HIV-1 in various cells. The EC(50)s for DXG were 0.032 mu M in CBMCs and
0.05 mu M in MT-4 cells, which were generally equipotent as 3TC. 3TC-resis
tant, but not AZT-resistant, HIV-1 had minimum diminished sensitivity to th
e compounds. Both DXG and DAPD were non-toxic to cells up to 500 mu M.