Citation
J. Machado et al., Antiviral activity and resistance profile of phosphazid - A novel prodrug of AZT, NUCLEOS NUC, 18(4-5), 1999, pp. 901-906
Citations number
7
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311
→ ACNP
Volume
18
Issue
4-5
Year of publication
1999
Pages
901 - 906
Database
ISI
SICI code
0732-8311(1999)18:4-5<901:AAARPO>2.0.ZU;2-I
Abstract
Both AZT and its novel 5'-hydrogen phosphonate derivative, Phosphazid, poss
ess similar in vitro activity and resistance profiles. Experiments involvin
g AZT-resistant virus isolates revealed a strong correlation between resist
ance to AZT and cross-resistance to Phosphazid. In vitro selection for resi
stance to Phosphazid yielded viruses that were about 15-fold less sensitive
than wild-type virus to this drug. Sequencing of the reverse transcriptase
region of seven Phosphazid-selected viruses revealed a single codon mutati
on, D67N, that is associated with resistance to AZT.