Effects of cycloSal-d4TMP derivatives in H9 cells with induced AZT resistance phenotype

Authors
Groschel, B Meier, C Zehner, R Cinatl, J Doerr, HW Cinatl, J
Citation
B. Groschel et al., Effects of cycloSal-d4TMP derivatives in H9 cells with induced AZT resistance phenotype, NUCLEOS NUC, 18(4-5), 1999, pp. 933-936
Citations number
8
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
4-5
Year of publication
1999
Pages
933 - 936
Database
ISI
SICI code
0732-8311(1999)18:4-5<933:EOCDIH>2.0.ZU;2-T
Abstract
Cytotoxic and antiretroviral activity of cycloSal-d4TMP derivatives were te sted in a new AZT-resistant H9 cell subline (H9(r)AZT(250)). The results sh owed, that cycloSal-d4TMP derivatives overcame resistance of HIV-1 to d4T i n H9(r)AZT(250) cells, which exert decreased thymidine kinase (TK) gene exp ression.