Prodrugs of Ara-CMP and Ara-AMP with a S-acyl-2-thioethyl (SATE) biolabilephosphate protecting group: Synthesis and biological evaluation

Authors
Bazzanini, R Manfredini, S Durini, E Groschel, B Cinatl, J Balzarini, J De Clercq, E Imbach, JL Perigaud, C Gosselin, G
Citation
R. Bazzanini et al., Prodrugs of Ara-CMP and Ara-AMP with a S-acyl-2-thioethyl (SATE) biolabilephosphate protecting group: Synthesis and biological evaluation, NUCLEOS NUC, 18(4-5), 1999, pp. 971-972
Citations number
2
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
4-5
Year of publication
1999
Pages
971 - 972
Database
ISI
SICI code
0732-8311(1999)18:4-5<971:POAAAW>2.0.ZU;2-J
Abstract
The bis(S-pivaloyl-2-thioethyl) phosphotriesters of Ara-C and Ara-A were sy nthesized as potential bioreversible mononucleotide prodrugs. Some N- and O -acylated derivatives were also prepared with the aim to modify the lipophi licity of the title pronucleotides. Compounds were tested far their antitum or/antiviral activity against a variety of tumor cells and viruses.