Synthesis and anti-HIV activity of some S-acyl-2-thioethyl (SATE) phosphoramidate derivatives of 3 '-azido-2 ',3 '-dideoxythymidine

Authors
Egron, D Perigaud, C Gosselin, G Aubertin, AM Imbach, JL
Citation
D. Egron et al., Synthesis and anti-HIV activity of some S-acyl-2-thioethyl (SATE) phosphoramidate derivatives of 3 '-azido-2 ',3 '-dideoxythymidine, NUCLEOS NUC, 18(4-5), 1999, pp. 981-982
Citations number
5
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
4-5
Year of publication
1999
Pages
981 - 982
Database
ISI
SICI code
0732-8311(1999)18:4-5<981:SAAAOS>2.0.ZU;2-G
Abstract
The synthesis and in vitro anti-HIV activity of tBuSATE phosphoramidate der ivatives of AZT incorporating several methyl-esterified alpha-aminoacids ar e reported. The biological evaluation strongly supports the hypothesis that such compounds exert their anti-HIV effects via intracellular delivery of the corresponding 5'-mononucleotide.