Synthesis and biological application of a new heterodinucleotide with bothanti-HSV and anti-HIV activity

Authors
Franchetti, P Abu Sheikha, G Cappellacci, L Grifantini, M Balestra, E Perno, CF Brandi, G Rossi, L Magnani, M
Citation
P. Franchetti et al., Synthesis and biological application of a new heterodinucleotide with bothanti-HSV and anti-HIV activity, NUCLEOS NUC, 18(4-5), 1999, pp. 989-990
Citations number
4
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
4-5
Year of publication
1999
Pages
989 - 990
Database
ISI
SICI code
0732-8311(1999)18:4-5<989:SABAOA>2.0.ZU;2-O
Abstract
A new antiviral drug with both anti-HSV and anti-HIV activity was synthesiz ed by coupling Acyclovir and the acyclic nucleoside phosphonate (R)PMPA. Th e heterodinucleotide ACVpPMPA encapsulated into autologous erythrocytes was added to human macrophages providing an effective in vitro protection from HSV-1 and HIV-1 replication.