Synthesis and in vitro antiviral activity of some symmetrical phosphoramidate dimers of AZT

Authors
Kers, I Girardet, JL Gosselin, G Perigaud, C Imbach, JL Stawinski, J
Citation
I. Kers et al., Synthesis and in vitro antiviral activity of some symmetrical phosphoramidate dimers of AZT, NUCLEOS NUC, 18(4-5), 1999, pp. 993-994
Citations number
3
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
4-5
Year of publication
1999
Pages
993 - 994
Database
ISI
SICI code
0732-8311(1999)18:4-5<993:SAIVAA>2.0.ZU;2-8
Abstract
The synthesis of some symmetrical phosphoramidate dimers of AZT is presente d. The synthetic scheme includes the formation of the symmetrical H-phospho nate diester of AZT, followed by its conversion to several dinucleoside pho sphoramidate analogues. The compounds were evaluated for their anti-retrovi ral activity.