Synthesis and transmembrane transport studies of lipophilic adenosine 5 '-triphosphate derivatives

Authors
Kreimeyer, A Andre, F Bluzat, A Gouyette, C Huynh-Dinh, T
Citation
A. Kreimeyer et al., Synthesis and transmembrane transport studies of lipophilic adenosine 5 '-triphosphate derivatives, NUCLEOS NUC, 18(4-5), 1999, pp. 995-999
Citations number
8
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
4-5
Year of publication
1999
Pages
995 - 999
Database
ISI
SICI code
0732-8311(1999)18:4-5<995:SATTSO>2.0.ZU;2-F
Abstract
The preparation of acyl adenosine 5'-triphosphates as potential membrane pe rmeable prodrugs is presented. The interaction of myristoyl- and cholestery loxy-carbonyl-ATP with liposomes as model membranes and the release of ATP inside these vesicles was investigated using an enzymatic assay as well as P-31-NMR spectroscopy.