Synthesis of the tBuSATE pronucleotide of AZT by two different synthetic approaches

Authors
Lannuzel, M Egron, D Imbach, JL Gosselin, G Perigaud, C
Citation
M. Lannuzel et al., Synthesis of the tBuSATE pronucleotide of AZT by two different synthetic approaches, NUCLEOS NUC, 18(4-5), 1999, pp. 1001-1002
Citations number
2
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
4-5
Year of publication
1999
Pages
1001 - 1002
Database
ISI
SICI code
0732-8311(1999)18:4-5<1001:SOTTPO>2.0.ZU;2-F
Abstract
A large scale synthesis of the tBuSATE pronucleotide of AZT was required fo r in vivo studies. A comparative synthesis of this derivative by phosphoram idite and monophosphate approaches is reported.