Vibrational study of a nucleoside analogue with antiviral activity, 5-chloro-2 '-deoxyuridine, CDU.

Authors
Bailey, L Navarro, R Hernanz, A
Citation
L. Bailey et al., Vibrational study of a nucleoside analogue with antiviral activity, 5-chloro-2 '-deoxyuridine, CDU., NUCLEOS NUC, 18(4-5), 1999, pp. 1069-1071
Citations number
6
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
4-5
Year of publication
1999
Pages
1069 - 1071
Database
ISI
SICI code
0732-8311(1999)18:4-5<1069:VSOANA>2.0.ZU;2-6
Abstract
The experimental FTIR and FT-Raman spectra of 5-chloro-2'-deoxyuridine have been assigned on the basis of normal coordinate analyses, in the light of observed and calculated wavenumbers and isotopic shifts. The results indica te that virtually all normal modes of IDU involve some degree of vibrationa l coupling between the chlorouracil base and the deoxyribose moiety.