Reactions of adenosine with bromo- and chloromalonaldehydes in aqueous solutions: Kinetics and mechanism

Authors
Koissi, N Ketomaki, K Neuvonen, K Kuusela, S Lonnberg, H
Citation
N. Koissi et al., Reactions of adenosine with bromo- and chloromalonaldehydes in aqueous solutions: Kinetics and mechanism, NUCLEOS NUC, 18(4-5), 1999, pp. 1095-1096
Citations number
2
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
4-5
Year of publication
1999
Pages
1095 - 1096
Database
ISI
SICI code
0732-8311(1999)18:4-5<1095:ROAWBA>2.0.ZU;2-E
Abstract
The kinetics of the reactions of adenosine with bromo- and chloromalon-alde hydes to give ethenoadenosine and ethenoformyladenosine has been studied un der various conditions. The rate of disappearance of adenosine and the prod uct distribution seen to be dependent on the halogen on the malonaldehyde. Different mechanistic alternatives are discussed, although definite conclus ions can not be drawn.