Role of tear inflammatory mediators in contact lens-associated giant papillary conjunctivitis in soft contact lens wearers

Contact lens-associated giant papillary conjunctivitis (CL-GPC) caused by m echanical and immune mechanisms is a significant problem resulting in conta ct lens intolerance and discontinuation of contact lens wear. In the presen t study, tear fluid leukotriene C-4 (LTC4) level was evaluated in soft cont act lens wearers with and without CL-GPC using ELISA. Statistical analysis showed no significant difference in tear fluid LTC4 between contact lens we arers without GPC and normal controls (p>0.05), but a significant increase in tear LTC4 level in CL-GPC patients (p<0.05). On the basis of this findin g, it might be possible to explain redness, conjunctival edema, increased m ucoid secretion, and papillary changes by the effect of LTC4 on eye tissues . Effective treatment of CL-GPC might be possible in the future by employin g inhibitors of leukotriene synthesis and action.