Extrahepatic Hodgkin's disease with intrahepatic cholestasis: Report of two cases

Liver is involved in about 5-8% of newly diagnosed Hodgkin's disease (HD) c ases. The incidence reaches up to 50-60% in postmortem studies. In the lite rature only a few cases of idiopathic cholestatic jaundice have been descri bed without an apparent cause and a paraneoplastic etiology has been sugges ted. We report 2 cases with HD presenting with obstructive jaundice without obvious liver involvement. The first case died soon after diagnosis; the s econd case received chemotherapy and radiotherapy, and she is well at 26 mo nths' follow-up. Extrahepatic HD with intrahepatic cholestasis is an extrem ely rare situation without an established approach. Such cases like the pre sent ones may help to understand the pathogenesis of the liver involvement of HD and determine the best management of these cases.