A major review of antimetabolites in glaucoma therapy

Antimetabolites have been used in combination with filtering surgery to imp rove surgical results for more than 10 years. Based on research published s ince the introduction of antimetabolites right up to date, we discuss the v arious forms of antimetabolites that have been used, including drugs and ir radiation. Among the drugs used, mitomycin C and 5-fluorouracil are the mos t prominent. We discuss the background of these agents, the progress in the use of antimetabolites and the research done on these drugs, These agents have been used both intra-operatively and perioperatively. We discuss the i ndications for their use, their mode of action, the techniques of usage, th eir variations as well as the complications and the treatment of complicati ons.