Binding affinities of gallotannin analogs with bovine serum albumin: ramifications for polyphenol-protein molecular recognition

Authors
Feldman, KS Sambandam, A Lemon, ST Nicewonger, RB Long, GS Battaglia, DF Ensel, SM Laci, MA
Citation
Ks. Feldman et al., Binding affinities of gallotannin analogs with bovine serum albumin: ramifications for polyphenol-protein molecular recognition, PHYTOCHEM, 51(7), 1999, pp. 867-872
Citations number
20
Categorie Soggetti
Agricultural Chemistry","Animal & Plant Sciences
Journal title
PHYTOCHEMISTRY
ISSN journal
00319422 → ACNP
Volume
51
Issue
7
Year of publication
1999
Pages
867 - 872
Database
ISI
SICI code
0031-9422(199908)51:7<867:BAOGAW>2.0.ZU;2-R
Abstract
A series of gallotannin analogs were prepared by chemical synthesis, and th eir affinity for the test-case protein bovine serum albumin was measured by equilibrium dialysis. The structure/activity data obtained suggest that th e naturally occurring gallotannins, in fact, do not represent the optimal p rotein recognition agents amongst polyphenolated templates. (C) 1999 Elsevi er Science Ltd. All rights reserved.