KINETIC RESOLUTION OF ALCOHOLS IN AN ASYMMETRIC MITSUNOBU REACTION USING CHIRAL NONRACEMIC 1,3,2-DIOXAPHOSPHEPANES

Authors
HULST R VANBASTEN A FITZPATRICK K KELLOGG RM
Citation
R. Hulst et al., KINETIC RESOLUTION OF ALCOHOLS IN AN ASYMMETRIC MITSUNOBU REACTION USING CHIRAL NONRACEMIC 1,3,2-DIOXAPHOSPHEPANES, Journal of the Chemical Society. Perkin transactions. I, (23), 1995, pp. 2961-2963
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
23
Year of publication
1995
Pages
2961 - 2963
Database
ISI
SICI code
0300-922X(1995):23<2961:KROAIA>2.0.ZU;2-J
Abstract
Non-racemic chiral trivalent phosphorus derivatives 1 and 2 when emplo yed under Mitsunobu reaction conditions, induce esterification between racemic alcohols and acids with moderate enantiospecificity (up to 39 %). At the expense of high conversion, the alcohols can be obtained in high ee (> 99%).