Evidence exists that in certain groups of workers exposed to volatile organ
ic chemicals, there is subclinical renal damage and dysfunction. Also, ther
e is activation of biological mechanisms that are suggested links between v
olatile organic chemical exposure and renal disease. Notably, the workers s
tudied are employed in factories where exposures are considered controlled
with on-site professional health and safety management. Recent studies cont
inue to indicate an increased risk of renal disease in those exposed to vol
atile organic chemicals.