A 57 years old man was operated for aortic valve replacement. During the op
erational a mediastinal lymph node was biopsed with the results of undiffer
entiated large cell carcinoma with neuroendocrine features. Three months af
ter surgery the patient died of non-cardiac related reasons, postmorten exa
mination was not performed. Although the primary tumor could not be assesse
d, probably the lung was the original location. The histological classifica
tion of lung cancer is exposed, with special reference in the undifferentia
ted large cell type with neuroendocrine feature.