Synthesis and biological evaluation of C-1 and ring modified A-norpaclitaxels

Authors
Yuan, HQ Kingston, DGI Long, BH Fairchild, CA Johnston, KA
Citation
Hq. Yuan et al., Synthesis and biological evaluation of C-1 and ring modified A-norpaclitaxels, TETRAHEDRON, 55(30), 1999, pp. 9089-9100
Citations number
22
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
55
Issue
30
Year of publication
1999
Pages
9089 - 9100
Database
ISI
SICI code
0040-4020(19990723)55:30<9089:SABEOC>2.0.ZU;2-O
Abstract
1-deisopropenyl-1-acetoxy-A-norpaclitaxel, 1-deisopropenyl-A-norpaclitaxel, 1-deisopropenyl-1-acetyl-8,9-oxido-A-norpaclitaxel, and A-nor-C-norpaclita xel were synthesized. The biological activities of these analogs were deter mined, and structure-activity relationships for the C-1 position are sugges ted. (C) 1999 Elsevier Science Ltd. All rights reserved.