Heterogeneous Henry reaction of aldehydes: Diastereoselective synthesis ofnitroalcohol derivatives over Mg-Al hydrotalcites.

Authors
Bulbule, VJ Deshpande, VH Velu, S Sudalai, A Sivasankar, S Sathe, VT
Citation
Vj. Bulbule et al., Heterogeneous Henry reaction of aldehydes: Diastereoselective synthesis ofnitroalcohol derivatives over Mg-Al hydrotalcites., TETRAHEDRON, 55(30), 1999, pp. 9325-9332
Citations number
27
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
55
Issue
30
Year of publication
1999
Pages
9325 - 9332
Database
ISI
SICI code
0040-4020(19990723)55:30<9325:HHROAD>2.0.ZU;2-Z
Abstract
Mg-Al Hydrotalcite (HT) has been found to catalyze the reaction between ald ehydes and nitroalkanes very efficiently affording three nitroalkanols in a highly diastereoselective manner. The ratios of threolerythro isomers are determined from their respective C-13-NMR spectra. A mechanism based on the transition state model for the predominant formation of threo-isomers is a lso described. (C) 1999 Elsevier Science Ltd. All rights reserved.