Extending the scope of Ruppert's reagent: trifluoromethylation of imines

Authors
Blazejewski, JC Anselmi, E Wilmshurst, MP
Citation
Jc. Blazejewski et al., Extending the scope of Ruppert's reagent: trifluoromethylation of imines, TETRAHEDR L, 40(30), 1999, pp. 5475-5478
Citations number
18
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
30
Year of publication
1999
Pages
5475 - 5478
Database
ISI
SICI code
0040-4039(19990723)40:30<5475:ETSORR>2.0.ZU;2-8
Abstract
The absence of reactivity of imines towards Ruppert's reagent (CF3SiMe3) co uld be overcome by the addition of an auxiliary silylating agent to the rea ction medium. Under these conditions variously substituted alpha-trifluorom ethylated amines are readily obtained from the corresponding imines. (C) 19 99 Published by Elsevier Science Ltd. All rights reserved.