A solid-phase equivalent of van Leusen's TosMIC, and its application in oxazole synthesis

Authors
Kulkarni, BA Ganesan, A
Citation
Ba. Kulkarni et A. Ganesan, A solid-phase equivalent of van Leusen's TosMIC, and its application in oxazole synthesis, TETRAHEDR L, 40(30), 1999, pp. 5633-5636
Citations number
18
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
30
Year of publication
1999
Pages
5633 - 5636
Database
ISI
SICI code
0040-4039(19990723)40:30<5633:ASEOVL>2.0.ZU;2-I
Abstract
Polystyrene-SH resin, prepared from Merrifield resin in two steps, was conv erted to polystyrene-SO2-CH2-NC in three steps. This resin functions as a s olid-phase equivalent of p-tolylsulfonylmethyl isocyanide (TosMIC). Thus, r eaction with aromatic aldehydes and tetrabutylammonium hydroxide as base yi elds 5-aryloxazoles. (C) 1999 Elsevier Science Ltd. All rights reserved.