Novel applications of ethyl glyoxalate with the Ugi MCR

Authors
Hulme, C Cherrier, MP
Citation
C. Hulme et Mp. Cherrier, Novel applications of ethyl glyoxalate with the Ugi MCR, TETRAHEDR L, 40(29), 1999, pp. 5295-5299
Citations number
25
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
29
Year of publication
1999
Pages
5295 - 5299
Database
ISI
SICI code
0040-4039(19990716)40:29<5295:NAOEGW>2.0.ZU;2-B
Abstract
This letter describes novel high-yielding solution phase preparations of 1, 4-benzodiazepine-2,5-dione, diketopiperazine, ketopiperazine and dihydroqui noxalinone libraries via a UDC (Ugi/de-Boc/cyclization) strategy in combina tion with ethylglyoxalate. The methodology represents a 'three step, one-po t procedure', employing the Ugi multi-component reaction (MCR), followed by Boc deprotection and cyclization. (C) 1999 Elsevier Science Ltd. All right s reserved.