Stereoselective substitution of alpha-aminoalkylferrocenes with diorganozincs. A fast synthesis of new chiral FERRIPHOS ligands for asymmetric catalysis

Authors
Lotz, M Ireland, T Perea, JJA Knochel, P
Citation
M. Lotz et al., Stereoselective substitution of alpha-aminoalkylferrocenes with diorganozincs. A fast synthesis of new chiral FERRIPHOS ligands for asymmetric catalysis, TETRAHEDR-A, 10(10), 1999, pp. 1839-1842
Citations number
8
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
10
Issue
10
Year of publication
1999
Pages
1839 - 1842
Database
ISI
SICI code
0957-4166(19990521)10:10<1839:SSOAWD>2.0.ZU;2-Q
Abstract
A direct stereoselective substitution of alpha-aminoalkylferrocenes of type 3 with organozinc reagents provides chiral ferrocenes which can be convert ed to the FERRIPHOS ligands of type 1 in a one-pot procedure. These FERRIPH OS ligands have been used for the Rh-catalyzed asymmetric hydrogenation of an enol acetate with 94.9% ee. (C) 1999 Elsevier Science Ltd. All rights re served.