A practical method for synthesis of terminal 1,2-diols in high enantiomeric excess via oxazaborolidine-catalyzed asymmetric reduction

Authors
Cho, BT Chun, YS
Citation
Bt. Cho et Ys. Chun, A practical method for synthesis of terminal 1,2-diols in high enantiomeric excess via oxazaborolidine-catalyzed asymmetric reduction, TETRAHEDR-A, 10(10), 1999, pp. 1843-1846
Citations number
22
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
10
Issue
10
Year of publication
1999
Pages
1843 - 1846
Database
ISI
SICI code
0957-4166(19990521)10:10<1843:APMFSO>2.0.ZU;2-E
Abstract
Asymmetric borane reduction of oc-hydroxy ketones protected with a tetrahyd ropyranyl (THP) group catalyzed by Corey's CBS reagent using N-phenylamine- borane complexes as the hydride source provided the corresponding terminal 1,2-diols with a very high enantiomeric excess. (C) 1999 Elsevier Science L td. All rights reserved.