Enantioselective trimethylsilylcyanation of aromatic aldehydes catalyzed by titanium alkoxide-chiral o-hydroxyarylphosphine oxides complexes

Authors
Brunel, JM Legrand, O Buono, G
Citation
Jm. Brunel et al., Enantioselective trimethylsilylcyanation of aromatic aldehydes catalyzed by titanium alkoxide-chiral o-hydroxyarylphosphine oxides complexes, TETRAHEDR-A, 10(10), 1999, pp. 1979-1984
Citations number
33
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
10
Issue
10
Year of publication
1999
Pages
1979 - 1984
Database
ISI
SICI code
0957-4166(19990521)10:10<1979:ETOAAC>2.0.ZU;2-C
Abstract
A series of new chiral titanium alkoxide-o-hydroxyarylphosphine oxides comp lexes has been used as catalysts in the asymmetric trimethylsilylcyanation of aromatic aldehydes. The corresponding cyanohydrins have been obtained in high chemical yields with good to excellent enantiomeric excesses up to 98 %. The influence of the structural features of the catalysts on the enantio selectivity has been investigated. (C) 1999 Elsevier Science Ltd. All right s reserved.