Urinary excretion of ceruloplasmin is elevated in the subjects with "borderline glucose tolerance test"

To examine whether or not there are any renal alterations in subjects with borderline glucose tolerance and in patients with non-insulin dependent dia betes mellitus (NIDDM) classified by the criteria of Japan Diabetic Associa tion, urinary excretions of plasma proteins including albumin, ceruloplasmi n (Cerulo) and IgG were measured in timed overnight urine samples. Eighty m iddle-aged, non-obese, normotensive, untreated men with urinary albumin exc retion rates below 20 mu g/minutes, beta(2)-microglobulin excretion rates b elow 140 mu g/minutes and creatinine clearance values exceeding 80 ml . min (-1) . (1.73 m(2))(-1) were included in this study. Three groups were defin ed according to the results of 75 g oral glucose tolerance test (OGTT) as f ollows: D group, 10 subjects with NIDDM; B group, 40 subjects with "borderl ine glucose tolerance test" and N group, 30 subjects with normal glucose to lerance. The fractional clearance (Theta) of Cerulo, but not albumin and Ig G, was elevated in 37.5% of the B group compared with the upper limit of th at of the N group. Furthermore, Theta-Cerulo and Theta-IgG increased in the D group compared with those of the N and the B groups. Recently, we found that Theta-Ceruloand Theta-IgG increased in healthy volunteers when CFR was elevated by acute protein loading and that increase in Theta-Cerulo is rem arkable than increase in Theta-IgG;. The present result, taken together wit h our recent finding mentioned above, suggests that increases in Theta-Ceru lo and Theta-IgG may not be due to an impairment of charge selectivity in t he glomerular basement membrane, but due to as increase of intraglomerular hydraulic pressure-(C) 1999 Tohoku University Medical Press.