The ecology of hepatitis E virus (HEV) transmission in South-East Asia was
assessed from a review of 6 published and 3 unpublished NAMRU-2 reports of
hepatitis outbreak investigations, cross-sectional prevalence studies, and
hospital-based case-control studies. Findings from Indonesia and Viet Nam s
how epidemic foci centred in jungle, riverine environments. In contrast, fe
w cases of acute, clinical hepatitis from cities in Indonesia, Viet Nam and
Laos could be attributed to HEV. When communities in Indonesia were groupe
d into areas of low (<40%), medium (40-60%), and high (>60%) prevalence of
anti-HEV antibodies, uses of river water for drinking and cooking, personal
washing, and human excreta disposal were all significantly associated with
high prevalence of infection. Conversely, boiling of river drinking water
was negatively associated with higher prevalence (P < 0.01). The protective
value of boiling river water was also shown in sporadic HEV transmission i
n Indonesia and in epidemic and sporadic spread in Viet Nam. Evidence from
Indonesia indicated that the decreased dilution of HEV in river water due t
o unusually dry weather contributed to risk of epidemic HEV transmission. B
ut river flooding conditions and contamination added to the risk of HEV inf
ection in Viet Nam. These findings attest to a unique combination of ecolog
ical and environmental conditions predisposing to epidemic HEV spread in So
uth-East Asia.