The recent introduction of tissue harmonic imaging could resolve the proble
ms related to ultrasound in technically difficult patients by providing a m
arked improvement in image quality. Tissue harmonics are generated during t
he transmit phase of the pulse-echo cycle, that is, while the transmitted p
ulse propagates through tissue. Tissue harmonic images are formed by utiliz
ing the harmonic signals that are generated by tissue and by filtering out
the fundamental echo signals that are generated by the transmitted acoustic
energy. To achieve this, two processes could be used; one by using filters
for fundamental and harmonic imaging and the second using two simultaneous
pulses with a 180 degrees difference in phase, The introduction of harmoni
cs allows increased penetration without a loss of detail, by obtaining a cl
earer image at depth with significantly less compromise to the image qualit
y caused by the use of lower frequencies. This imaging mode could be used i
n different organs with a heightening of low-contrast lesions through artef
act reduction, as well as by the induced greater intrinsic contrast sensiti
vity of the harmonic imaging mode. (C) 1999 World Federation for Ultrasound
in Medicine & Biology.