R. Oberhoffer et al., Cardiac changes in fetuses secondary to immune hemolytic anemia and their relation to hemoglobin and catecholamine concentrations in fetal blood, ULTRASOUN O, 13(6), 1999, pp. 396-400
Objectives Immune hemolytic anemia in the fetus may cause cardiac decompens
ation and intrauterine death. Postnatally, norepinephrine (noradrenaline) i
s released in chronic heart failure and may lead to myocardial hypertrophy
The aim of this study was to determine fetal cardiac changes associated wit
h immune hemolytic anemia by means of echocardiography, and to relate them
to fetal hemoglobin and norepinephrine levels.
Design Thirty anemic fetuses underwent a total of 76 umbilical venous trans
fusions. Before the procedure, fetal echocardiography was performed, Lend e
nd-diastolic myocardial wall thicknesses and ventricular dimensions togethe
r with Doppler flow patterns at the atrioventricular and semilunar valves w
ere measured Fetal hemoglobin, epinephrine and norepinephrine concentration
s were determined before the transfusion. Statistical analysis of this pros
pective study comprised descriptive statistics including linear regression
and correlation analyses. Two samples of measurements were compared by the
Mann-Whitney U test.
Results The mean hemoglobin concentration before the first transfusion was
6.9 g% at a mean gestational age of 26.8 weeks. Norepinephrine values were
elevated in comparison to a reference range, and were higher than epinephri
ne values. The most striking echocardiographic finding was myocardial hyper
trophy of all ventricular walls. Mean blood flow velocities were increased;
at the left ventricle, they were negatively related to the hemoglobin conc
entrations, and positively to the norepinephrine values.
Conclusions Fecal myocardial hypertrophy in anemia may be the result of an
augmented cardiac workload, indicated by the increased left ventricular mea
n velocities. This reaction reflects the redistribution of blood flow that
may depend on hemoglobin and norepinephrine concentrations.