Hepatoid adenocarcinoma of the urinary bladder - An unusual neoplasm

A new case of hepatoid adenocarcinoma was diagnosed in fragments obtained a t transurethral resection (TUR) from a 71-year-old man who had complained o f haematuria. The tumour was composed of trabeculae and small solid nests o f polygonal atypical cells simulating hepatocarcinoma, together with glandu lar areas of an otherwise typical adenocarcinoma. Immunohistochemistry show ed cytoplasmic reactivity to AFP, AAT, albumin and CAM 5.2. Membrane reacti vity was seen in EMA immunostaining, and there was also positivity to polyc lonal CEA following a canalicular pattern. Immunoperoxidase studies of hepa tocyte growth factor (HGF) and its receptor, c-met, were positive. Their ex pression may be related to the aggressive behaviour of this tumour.