Assessment of myocardial metaiodobenzylguanidine uptake and its relation to left ventricular systolic and diastolic functional parameters in dilated cardiomyopathy

The purpose of this study was to assess the relation between myocardial met aiodobenzylguanidine (MIBG) uptake and left ventricular systolic and diasto lic functional parameters, both of which are known as predictors of prognos is in patients with dilated cardiomyopathy. Echocardiography and iodine-123 -MIBG myocardial scintigraphy were performed in 35 patients of dilated card iomyopathy with normal sinus rhythm. Mean myocardial MIBG uptake in the pat ient group ar: early and delayed images were significant ly lower than thos e in normal control subjects (10.6+/-1.1, 9.8+/-1.2 vs 12.4+/-1.0, 12.1+/-1 .0, p<0.01). There were, however, no significant differences of mean MIBG u ptake in the lung and mediastinum between the two groups (p>0.05). There we re no significant: correlations between myocardial MIBG uptake, expressed a s the ratio of heart/mediastinum MIBG activity at delayed image, and left v entricular systolic and diastolic functional parameters (left ventricular e jection fraction, left ventricular end-diastolic dimension, peak velocity o f early diastolic Filling (E velocity), deceleration time of E wave, cardia c output, left ventricular end-diastolic pressure). In conclusion, the myoc ardial uptake of MIBG is decreased in patients with dilated cardiomyopathy assessed by iodine-123-MIBG myocardial scintigraphy. There were, however, n o significant correlations between myocardial MIBG uptake and left ventricu lar systolic and diastolic functional parameters derived from echocardiogra phy.