Factor XIII: experimental and clinical results in treatment of patients with diabetic foot ulcer

Several diseases show an impairment of vascular barrier function. In the pa st, we found out that topically applied plasmatic factor XIII distinctly re duced secretion tendency and improved granulation in venous ulcer. Increase d vascular permeability is also discussed in patients with a long lasting d iabetic status being a relevant cause of impaired local wound healing. Ther efore, we introduced the topical application of factor XIII into the therap y of diabetic foot ulcer. After basic experimental investigations revealed that factor XIII significantly reduces endothelial permeability of cultured endothelial cells, the first clinically treated diabetic patients showed e ncouraging results, too.