Several diseases show an impairment of vascular barrier function. In the pa
st, we found out that topically applied plasmatic factor XIII distinctly re
duced secretion tendency and improved granulation in venous ulcer. Increase
d vascular permeability is also discussed in patients with a long lasting d
iabetic status being a relevant cause of impaired local wound healing. Ther
efore, we introduced the topical application of factor XIII into the therap
y of diabetic foot ulcer. After basic experimental investigations revealed
that factor XIII significantly reduces endothelial permeability of cultured
endothelial cells, the first clinically treated diabetic patients showed e
ncouraging results, too.