Severe end of Opitz trigonocephaly (C) syndrome or new syndrome?

Opitz trigonocephaly (C)-like syndrome with a highly characteristic combina tion of facial anomalies including prominent metopic suture, exophthalmos, hypertelorism, cleft lip and palate, flexion deformities of the upper limbs and multiple other anomalies. We also review two very similar published ca ses formerly considered to have the C syndrome. Although there is overlap, a clinical distinction from the Opitz trigonocephaly and other syndromes se ems possible, and thus a specific causal entity may be postulated. (C) 1999 Wiley-Liss, Inc.