OBJECTIVE: Before the availability of modern imaging studies the diagnosis
of septic pelvic thrombophlebitis causing prolonged puerperal fever was dif
ficult to confirm without surgical exploration. With the use of computed to
mography infection-related pelvic phlebitis can now be confirmed, and this
study was designed to determine its incidence after delivery. We also desig
ned a randomized clinical trial to evaluate the efficacy of heparin added t
o antimicrobial therapy for treatment of women with septic phlebitis.
STUDY DESIGN: We studied women who had pelvic infection and fever that pers
isted after 5 days despite adequate antimicrobial therapy with clindamycin,
gentamicin, and ampicillin. After giving consent study participants underw
ent abdominopelvic computed tomographic imaging. Women with pelvic thrombop
hlebitis were randomly assigned to 1 of 2 management schemes that included
continuation of antimicrobial therapy, either alone or with the addition of
heparin, until the temperature was less than or equal to 37.5 degrees C fo
r 48 hours.
RESULTS: During the 3-year study period 44,922 women were delivered at Park
land Hospital; among these 8535 (19%) were delivered by the cesarean route.
There were 69 women who met criteria for prolonged infection, and 15 (22%)
of these were found to have septic pelvic thrombophlebitis. Four had infec
tion after vaginal delivery and 11 had been delivered by the cesarean route
. Of 14 women randomly assigned to therapy, 8 were assigned to receive cont
inued antimicrobial therapy without the addition of heparin and the other 6
were assigned to receive heparin therapy in addition to the antimicrobial
agents. According to an intent-to-treat analysis there was no significant d
ifference between the responses of women with pelvic infection who were and
were not given heparin therapy. Specifically, women not given heparin were
febrile for 140 +/- 39 hours compared with 134 +/- 65 hours for women who
received heparin (P = .83). Duration of hospitalization was also similar be
tween the 2 groups at 10.6 +/- 1.9 days for those with thrombosis who were
given antimicrobial agents alone and 11.3 +/- 1.2 days for women who also r
eceived heparin (P > .5). The 54 women with persistent fever but without co
mputed tomographic evidence of septic pelvic thrombophlebitis were hospital
ized for a mean of 12.0 +/- 4.1 days, compared with 10.9 +/- 2.9 days for w
omen in whom thrombosis was diagnosed (P = .14). These women were followed
up for greater than or equal to 3 months post partum and none showed eviden
ce of reinfection, embolic episodes, or postphlebitic syndrome.
CONCLUSIONS: The overall incidence of septic pelvic thrombophlebitis was 1:
3000 deliveries. The incidence was about 1:9000 after vaginal delivery and
1:800 after cesarean section. Women given heparin in addition to antimicrob
ial therapy for septic thrombophlebitis did not have better outcomes than d
id those for whom antimicrobial therapy alone was continued. These results
also do not support the common empiric practice of heparin treatment for wo
men with persistent postpartum infection.