Twenty-three patients with acute anterior cruciate ligament injuries, norma
l radiographs, and occult osteochondral lesions revealed by magnetic resona
nce imaging were reviewed 6 years after initial injury and anterior cruciat
e ligament hamstring autograft reconstruction. Each patient completed the M
ohtadi Quality of Life outcome measure for anterior cruciate ligament defic
iency, underwent clinical examination, and had a repeat magnetic resonance
imaging scan. The index and follow-up magnetic resonance imaging scans were
compared with respect to cartilage thinning and marrow signal. A significa
nt number of patients had evidence of cartilage thinning adjacent to the si
te of the initial osteochondral lesion. Marrow signal changes persisted in
15 (65%) of the patients. Clinical comparison of patients with normal carti
lage with those who had cartilage thinning revealed similar results on both
KT-1000 arthrometry and on the Mohtadi outcome measure. This suggests that
the initial injury resulted in irreversible changes in the knee. Injuries
causing marrow signal changes may result in an alteration in the load-beari
ng properties of subchondral bone, which in turn allow for changes in the o
verlying cartilage. Further follow-up will determine the clinical significa
nce of changes detected by magnetic resonance imaging.