Extent of chest wall invasion and survival in patients with lung cancer

Background. The long-term survival after operation of patients with lung ca ncer involving the chest wall is known to be related to regional nodal invo lvement and completeness of resection, but it is not known whether the dept h of chest wall involvement or the type of resection (extrapleural or en bl oc) affects either the rate of local recurrence or survival. Methods. We retrospectively reviewed the Memorial Sloan-Kettering Cancer Ce nter experience between 1974 and 1993 of 334 patients undergoing surgical e xploration for lung cancer involving the chest wall or parietal pleura. Results. Of 334 patients who underwent exploration, 175 had apparently comp lete (R0) resections, 94 had incomplete (R1 or R2) resections, and 65 under went exploration without resection. The overall 5-year survival of R0 patie nts was 32%, of R1 or R2 patients 4%, and of patients undergoing exploratio n without resection 0%. In the patients undergoing R0 resections, the exten t of chest wall involvement was limited to the parietal pleura in 80 patien ts, and extended into the ribs or soft tissues in 95. The 5-year survival o f R0 patients with T3 N0 M0 disease was 49%, T3 N1 M0 disease 27%, and T3 N 2 M0 disease 15% (p < 0.0003). Independent of lymph node involvement, a sur vival advantage was observed in R0 patients if the chest wall involvement w as limited to parietal pleura only, rather than invading into the chest wal l musculature or ribs. Conclusions. Survival of patients with lung cancer invading the chest wall after resection with curative intent is highly dependent on the extent of n odal involvement and the completeness of resection, and much less so on the depth of chest wall invasion. (C) 1999 by The Society of Thoracic Surgeons .