Mj. Krasna et al., Lung cancer staging and treatment in multidisciplinary trials: Cancer and leukemia group B cooperative group approach, ANN THORAC, 68(1), 1999, pp. 201-207
Citations number
16
Categorie Soggetti
Cardiovascular & Respiratory Systems","Medical Research Diagnosis & Treatment
Background. Aggressive routine surgical staging is necessary to evaluate pa
tients to be treated on cooperative oncology protocols. Less than 1% of lun
g cancer patients in the United States are currently being treated in a cli
nical trial. Only with results from large, prospective trials can the quest
ions of neoadjuvant and adjuvant therapy be answered.
Methods. An outline describing the schema of preoperative patient evaluatio
n, surgical staging, and the definition of surgical staging and resection p
rocedures appropriate for patients considered for cooperative group protoco
l is presented. Current Cancer and Leukemia Group B (CALGB) protocols are u
sed in the discussion as examples of this systematic approach.
Conclusions. Over the next few years, it will be important to enter the max
imum number of patients into combined modality studies to identify the role
of neoadjuvant treatment in lung cancer. Entry of patients into protocols
will also make their pathological specimens and clinical information availa
ble for basic science research related to treatment results. Adherence to a
logical sequence of patient evaluation as outlined above will optimize pat
ient care, as well as accrual to cooperative group studies. (C) 1999 by The
Society of Thoracic Surgeons.