A conserved RGD (Arg-Gly-Asp) motif in the transferrin receptor is required for binding to transferrin

Authors
Dubljevic, V Sali, A Goding, JW
Citation
V. Dubljevic et al., A conserved RGD (Arg-Gly-Asp) motif in the transferrin receptor is required for binding to transferrin, BIOCHEM J, 341, 1999, pp. 11-14
Citations number
25
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHEMICAL JOURNAL
ISSN journal
02646021 → ACNP
Volume
341
Year of publication
1999
Part
1
Pages
11 - 14
Database
ISI
SICI code
0264-6021(19990701)341:<11:ACR(MI>2.0.ZU;2-U
Abstract
The transferrin receptor contains a highly conserved Arg-Gly-Asp (RGD) sequ ence in the C-terminal region where transferrin is thought to bind. RGD seq uences are commonly involved in cell adhesion. This sequence is crucial for transferrin binding, suggesting possible evolutionary links between molecu les mediating iron uptake and cell adhesion.