M. Kawamukai, Isolation of a novel gene, moc2, encoding a putative RNA helicase as a suppressor of sterile strains in Schizosaccharomyces pombe, BBA-GENE ST, 1446(1-2), 1999, pp. 93-101
Citations number
30
Categorie Soggetti
Molecular Biology & Genetics
Journal title
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
A novel gene designated moc2, which encodes a putative RNA helicase, was is
olated from Schizosaccharomyces pombe on the basis of its suppression of th
e sterility of two different mutant strains, one of which had elevated leve
ls of cAMP and the other deregulated Ras functioning as a result of an ecto
pic expression of dominant negative RAS2. Moc2 is highly homologous to the
RNA helicase DED1 of Saccharomyces cerevisiae (58% identity) and PL10 of mo
use (50% identity). Disruption of the moc2 gene indicated that moc2 is esse
ntial for cell growth. The moc2 gene seems to have roles in both sexual dif
ferentiation and cell growth. (C) 1999 Elsevier Science B.V. All rights res
erved.