Physico-chemical characterization of meglumine antimoniate

Authors
Demicheli, C de Figueiredo, TL Carvalho, S Sinesterra, RD Lopes, JCD Frezard, F
Citation
C. Demicheli et al., Physico-chemical characterization of meglumine antimoniate, BIOMETALS, 12(1), 1999, pp. 63-66
Citations number
8
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOMETALS
ISSN journal
09660844 → ACNP
Volume
12
Issue
1
Year of publication
1999
Pages
63 - 66
Database
ISI
SICI code
0966-0844(199903)12:1<63:PCOMA>2.0.ZU;2-G
Abstract
The leishmanicidal drug, meglumine antimoniate (MA), has been synthesized b y the reaction of antimony oxyhydrated and N-methyl glucamine. Infrared and solid state NMR C-13 analysis of MA and the ligand strongly suggests that antimony binds to N-methyl glucamine through the oxygen of C-3 carbon. Pote ntiometric titration indicated that, between pH 4.5 and 7.5, MA exists in t he zwitterionic form.