M. Ortega et al., Follow-up of chimerism in children with hematological diseases after allogeneic hematopoietic progenitor cell transplants, BONE MAR TR, 24(1), 1999, pp. 81-87
Citations number
28
Categorie Soggetti
Hematology,"Medical Research Diagnosis & Treatment
Using in situ hybridization with an X and Y chromosome probe mixture, 106 b
one marrow samples from 38 patients with malignant and non-malignant hemato
logical diseases who received sex-mismatched allogeneic hematopoietic proge
nitor cell transplants (PCT) in a single institution within short-term inte
rvals (1, 3, 6, 12, 24 and >24 months) have been sequentially studied. The
patients received either HLA-identical (n = 31) or nonidentical (n = 7) PCT
, Twenty-six children showed donor chimerism, 10 children showed mixed chim
erism (MC) and two children presented autologous reconstitution. Chimerism
status with different parameters has been related (age, sex, donor, disease
status before PCT, conditioning regimen, GVHD prophylaxis, relapse, GVHD a
nd survival), Our results indicate that female patients (P = 0.011) and a l
ess intensive conditioning regimen (P = 0.039) are significantly associated
with the MC status, Mixed chimerism is not, per se, significantly associat
ed with leukemia relapse but an increase of the MC is indicative of clinica
l relapse.