A man with natural killer cell lymphoma showing 46,XX and deletion 6q

Specific chromosomal abnormalities have been shown to be associated with ce rtain types of leukemia and lymphoma. We and others have recently demonstra ted del(6)(q21q25) as being strongly associated with natural killer cell ly mphoma/leukemia. In this report, we describe a case of natural killer cell lymphoma with a clonal chromosomal abnormality of 46,X,- Y,+X,t(2;9)(q31;p2 4), del(4)(q21q25),del(6)(q22q23), and propose that the region 6q23 is prob ably an important site of genetic alteration in this group of tumors. (C) E lsevier Science Inc., 1999. All rights reserved.