Translocations (X;10)(p22;q24) and (1;10)(q21;q11) in a follicular adenomaof the thyroid without apparent involvement of the RET protooncogene

We report here the cytogenetic analysis of a follicular adenoma of the thyr oid which revealed an abnormal clone with a t(X;10)(p22;q24) and a t(1;10)( q21;q11) together with normal cells. Fluorescence in situ hybridization (FI SH) with YACs 273E3 and 344H4, which are located on 10q11.2 and are specifi c for the RET protooncogene, showed no abnormalities. It would therefore ap pear that this gene is not involved in this particular tumor, as has been r eported in a number of papillary thyroid carcinomas. Several chromosomal ab errations have been suggested as being specific for follicular thyroid aden oma. However, until now, only a few such cases have been reported which inv olve structural abnormalities of chromosomes 10q11.2 and 10q24. We believe this to be the first report of a follicular thyroid adenoma with a t(X;10) and a t(1;10). (C) Elsevier Science Inc., 1999. All rights reserved.